E3 ligase Ligand 10

E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a 2-unit PEG linker, utilized in PROTAC technology.

E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.

(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC comprising the (S,R,S)-AHPC based VHL ligand and a 6-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1].

E3 Ligase Ligand-linker Conjugate 28, a combination of E3 ligase ligand and linker comprising Thalidomide and its corresponding linker, acts as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate in synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 45, a conjugate of E3 ligase ligand and linker, consists of Thalidomide and the corresponding Linker. It can serve as a Cereblon ligand to recruit CRBN protein and acts as a key intermediate for synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 50 comprises a VH032-based von Hippel-Lindau (VHL) ligand known as (S,R,S)-AHPC and a corresponding linker. This conjugate specifically involves the combination of an E3 ligase ligand and a linker, where (S,R,S)-AHPC functions to recruit VHL proteins. It serves as a crucial intermediate in synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 51, a compound comprising Thalidomide and its corresponding linker, functions as a Cereblon ligand to recruit CRBN protein and is a crucial intermediate in the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 58, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. This compound acts as a Cereblon ligand, recruiting CRBN protein, and serves as a crucial intermediate for synthesizing complete PROTAC molecules.

E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

E3 Ligase Ligand 21 (compound 2), a cereblon binder, facilitates the degradation of Ikaros or Aiolos via the ubiquitin proteasome pathway [1].

E3 Ligase Ligand-linker Conjugate 48, a conjugate of E3 ubiquitin ligase ligand-Linker, is utilized for synthesizing complete PROTACs molecules.

E3 Ligase Ligand-linker Conjugate 5, a combination of an E3 ligase ligand and linker, comprises Thalidomide and its specific Linker. This conjugate acts as a Cereblon ligand to attract the CRBN protein and functions as a crucial intermediate in the production of full PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 7, a conjugate of E3 ligase ligand and linker, consists of Thalidomide and the corresponding Linker. It serves as a Cereblon ligand to recruit CRBN protein and is a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand 22 (compound 139) serves as a cereblon binder, facilitating the degradation of Ikaros or Aiolos via the ubiquitin proteasome pathway [1].

E3 Ligase Ligand-Linker Conjugate 34 comprises Thalidomide linked to a corresponding linker, serving as a conjugate between an E3 ligase ligand and a linker. This compound acts as a cereblon ligand, recruiting the CRBN protein and functioning as an essential intermediate in the synthesis of complete PROTAC molecules.

cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].

E3 Ligase Ligand-linker Conjugate 91, a conjugate of an E3 ligase ligand and linker, consists of (S,R,S)-AHPC and the corresponding linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. This conjugate serves as a key intermediate for synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 15, a conjugate of E3 ubiquitin ligase ligand-linker, can be utilized for synthesizing complete PROTACs molecules.

E3 ligase Ligand-Linker Conjugate 39, a conjugate of an E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. This conjugate can act as a Cereblon ligand to recruit CRBN protein and serve as a crucial intermediate in the synthesis of complete PROTAC molecules.

E3 ligase Ligand 14 binds to E3 ubiquitin ligase and, when conjugated to a protein ligand via a linker, forms PROTACs that facilitate the ubiquitination-mediated degradation of cancer-promoting proteins[1].

E3 Ligase Ligand PG serves as an E3 ligase ligand capable of recruiting the CRBN protein. It demonstrates strong binding affinity with CRBN, exhibiting an IC50 of 2.191 μM. Furthermore, E3 Ligase Ligand PG can be linked via a linker to BMS-202 to form PROTAC, PROTACPD-L1degrader-1.

E3 Ligase Ligand-linker Conjugate 54 comprises Thalidomide and a corresponding linker, serving as a conjugate between the E3 ligase ligand and the linker. This compound acts as a Cereblon ligand to recruit CRBN protein, playing a vital role as an intermediate in synthesizing complete PROTAC molecules.

TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].

PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

E3 ligase Ligand 18 is a compound that binds to E3 ubiquitin ligase and can be chemically linked to a protein ligand via a linker to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins [1].

E3 ligase Ligand 9 is a compound that acts as a ligand for E3 ubiquitin ligase and can be attached to a protein ligand via a linker to form PROTACs or SNIPERs, which degrade cancer-promoting proteins through ubiquitination-mediated mechanisms[1].

E3 Ligase Ligand 7 (Compound 6) serves as a ligand for E3 ligase. It is utilized in the synthesis of PROTAC BET Degrader-12.

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising an (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications.

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate, incorporating an (S,R,S)-AHPC-based VHL ligand and a linker[1].

Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].